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pentobarbital will lower the extent or effect of parecoxib by impacting hepatic enzyme CYP2C9/10 metabolism. Use Warning/Monitor.pentobarbital will decrease the extent or effect of mavacamten by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.Watch Intently (one)pentobarbital will lower the extent or effect of buprenorphine